Padget's Disease

Padget's DiseasePadget’s Disease refers to two distinct disease conditions ( of breast and of bone) which have nothing in common except being named for the physician who first described them, Sir James Padget (1814 - 1899).

Padget’s Disease of the breast is a rare condition almost always associated with underlying breast cancer, usually invasive or intraductal carcinoma. It is associated with a red, scaly lesion on the nipple and surrounding tissue, and there may or may not be a discharge from the nipple. Sometimes in early stages of the condition it may be misdiagnosed as eczyma, dermatitis or psoriasis, if signs of the underlying cancer are not readily apparent.

Padget’s Disease is characterized by inflammatory cells that are large and irregular, as first described by Padget. These Padget’s cells are not themselves cancerous and when found on other parts of the body are not associated with cancer.

The presence of Padget’s Disease with breast cancer does not materially affect the treatment or prognosis of the cancer. Indeed, its primary importance may be in those early stages of cancer to cause the physician to look for cancer when there are no readily observed symptoms (lump) to suggest breast cancer.